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KMID : 0381219850170010056
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Journal of RIMSK
1985 Volume.17 No. 1 p.56 ~ p.61
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Antibody Positive Rate of Cytomegalovirus by ELISA in Primary
School Children in Ahn Sung Gun, Kyeonggi Do
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Abstract
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The cytomegalovirus infection is world-wide in distribution and has the highest prevalence rates among young children, particulary those living under the crowded, intimate condition. This is probably one of the most common cause of congenital infection, which may frequently remain severe somatic or functional sequelae in human life. The mode of natural transmission of virus from mother to fetus is ill defined because of the usual lack of either maternal or fetal signs and symptoms. Maternal cytomegalovirus infection, especially in genital tract and the role of recurrent infection in the intrauterine transmission is poorly understood. The infection may be congenital, but it is most often acquired in the perinatal or postnatal period. The prevalence of congenital infection has been found to vary from 0.5 to 2.0 percent at birth from 10 to 56 percent at six month of age. The rate of serologic positivity increases slowly through childhood. During adolescence positive rate of cytomegalovirus antibody may rise significantly from 40 to 100 percent. The incidence of seropositivity also varies greatly depending on the socioeconomic status and living conditions.
Recently, the ELISA test is an available method to determine the presence of cytomegalovirus IgG antibody, and with the antibody titer of higher than 1 : 44 being considered positive. So, the antibody titers of cytomegalovirus were surveyed by ELISA.
The samples for this study were obtained from 172 children(from 6 to 12yr old age) of primary school located in Ahn-Sung Gun, Kyeonggi Do, Korea, June, 1984. There is a great significance for antibody positive rate against cytomegalovirus in rural area, because of comparing with the previous study in urban area.
The results of this study are summarized as follows.
1) With the antibody titer of higher than 1 : 44 being considered positive, the antibody
positive rate was 91.3%´(157 among 172 populations).
2) On the view point of sexual difference, the antibody positive rate was 89. 3% (92 among 103 populations) in male, and was 94.2% (65 among 69 populations) in female. This results are no statistical difference (x2=1.237).
3) The antibody positive rates did not show any statistical difference according to age group (x2 - 1.368).
4) The comparison of antibody positive rate in sex between :=eou1 and Ahn-Sung did not show statistical difference (x2 0.042).
5) The comparison of antibody positive rate in age between Seoul and Ahn-Sung showed statistical difference (x2=26.542; p<0.01).
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